FGF-23 is a biomarker of RV dysfunction and congestion in patients with HFrEF. Benes J, Kroupova K, Kotrc M, Petrak J, Jarolim P, Novosadova V, Kautzner J, Melenovsky V.  Sci Rep. 2023 Sep 25;13(1):16004. doi: 10.1038/s41598-023-42558-4. (IF 18.2) [Pubmed] 

Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review. Tkachenko A, Onishchenko A, Myasoedov V, Yefimova S, Havranek O. Nanotoxicology. 2023 Apr 21:1-31. doi: 10.1080/17435390.2023.2203239. (IF 5.88) [PubMed]

CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology. Knizkova D, Pribikova M, Draberova H, Semberova T, Trivic T, Synackova A, Ujevic A, Stefanovic J, Drobek A, Huranova M, Niederlova V, Tsyklauri O, Neuwirth A, Tureckova J, Stepanek O, Draber P. Nat Immunol. 2022 Oct 21. doi: 10.1038/s41590-022-01325-9. (IF 31.25) [PubMed] 

G-CSF plus azacitidine versus azacitidine alone for patients with high-risk myelodysplastic syndrome: academic, open label, randomized trial. Stopka T, Minařík L, Dusilková N, Pešta M, Kulvait V, Špaček M, Zemanová Z, Kalousová M, Jonášová A. Blood Cancer J. 2022 Jul 7;12(7):105. doi: 10.1038/s41408-022-00698-2. (IF 11.98) [PubMed]

Rozhovor pro UK FORUM: Nová kombinace léčiv prodlužuje život pacientů s leukémií (ukforum.cz)

TZ BIOCEV: Čeští lékaři a vědci prodlouží život lidem s leukémií | Biocev

Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents. Bašová P, Paszeková H, Minařík L, Dluhošová M, Burda P, Stopka T.  Int J Mol Sci. 2022 Jun 16;23(12):6729. doi: 10.3390/ijms23126729. (IF 5.9) [PubMed]

Circulating microRNAs in Cerebrospinal Fluid and Plasma: Sensitive Tool for Detection of Secondary CNS Involvement, Monitoring of Therapy and Prediction of CNS Relapse in Aggressive B-NHL Lymphomas. Krsmanovic P, Mocikova H, Chramostova K, Klanova M, Trnkova M, Pesta M, Laslo P, Pytlik R, Stopka T, Trneny M, Pospisil V.  Cancers. 2022; 14(9):2305. https://doi.org/10.3390/cancers14092305. (IF 6.6) (Web)

Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P.  Mol Cancer Ther. 2022 Jan;21(1):89-99. doi: 10.1158/1535-7163.MCT-21-0511. Epub 2021 Nov 2. (IF 6.3) [PubMed] 

 Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways. Minařík L, Pimková K, Kokavec J, Schaffartziková A, Vellieux F, Kulvait V, Daumová L, Dusilková N, Jonášová A, Vargová KS, Králová Viziová P, Sedláček R, Zemanová Z, Stopka T. Cells. 2022; 11(2):223. https://doi.org/10.3390/cells11020223. (IF 6.6) [PubMed]

Detecting Förster resonance energy transfer in living cells by conventional and spectral flow cytometry. Henderson J, Havranek O, Ma MCJ, Herman V, Kupcova K, Chrbolkova T, Pacheco-Blanco M, Wang Z, Comer JM, Zal T, Davis RE.  Cytometry A. 2021 Jun 14. doi: 10.1002/cyto.a.24472. (IF 4.355) [PubMed] 

Exosomes released by imatinib-resistant K562 cells contain specific membrane markers, IFITM3, CD146 and CD36 and increase the survival of imatinib-sensitive cells in the presence of imatinib. Hrdinova T, Toman O, Dresler J, Klimentova J, Salovska B, Pajer P, Bartos O, Polivkova V, Linhartova J, Machova Polakova K, Kabickova H, Brodska B, Krijt M, Zivny J, Vyoral D and Petrak J. Int. J. Oncol. 58: 238-250, 2021. (IF 3.899) (Pubmed)      

Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes. Pribyl M, Hubackova S, Moudra A, Vancurova M, Polackova H, Stopka T, Jonasova A, Bokorova R, Fuchs O, Stritesky J, Salovska B, Bartek J, Hodny Z.  Mol Oncol. 2020 Oct;14(10):2403-2419. doi: 10.1002/1878-0261.12768. (IF 6.574) [PubMed] 

CD31/PECAM-1 impacts engraftment, growth and spread of mantle cell lymphoma cells and positively correlates with extramedullary involvement. Vockova P, Molinsky J, Klanova M, Karban J, Spacek M, Havranek O, Kupcova K, Kazantsev D, Trneny M, Klener P. Leuk Lymphoma. 2020 Nov 25:1-8. doi: 10.1080/10428194.2020.1849678. (IF 2.969) [PubMed]

Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma. Jain N, Singh S, Laliotis G, Hart A, Muhowski E, Kupcova K, Chrbolkova T, Khashab T, Chowhury SM, Sircar A, Shirazi F, Singh RK, Alinari L, Zhu J, Havranek O, Tsichlis P, Woyach J, Baiocchi R, Samaniego F, Sehgal L. Blood Adv. 2020;4(18):4382-4392. doi:10.1182/bloodadvances.2020001685. (IF 4.584) [Pubmed]  

Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop. Draberova H, Janusova S, Knizkova D, Semberova T, Pribikova M, Ujevic A, Harant K, Knapkova S, Hrdinka M, Fanfani V, Stracquadanio G, Drobek A, Ruppova K, Stepanek O, Draber Peter. [published online ahead of print, 2020 Jul 21]. EMBO J. 2020;e104202. doi:10.15252/embj.2019104202. (IF 9.889) [Pubmed]

Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion. Zikmund T, Paszekova H, Kokavec J, Kerbs P, Thakur S, Turkova T, Tauchmanova P, Greif PA, Stopka T.  Int J Mol Sci. 2020;21(6):E2073. Published 2020 Mar 18. doi:10.3390/ijms21062073. (IF 4.183) [PubMed]
 

Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma. Bucher P, Erdmann T, Grondona P, Xu W, Schmitt A, Schürch C, Zapukhlyak M, Schönfeld C, Serfling E, Kramer D, Grau M, Klener P, Lengerke C, Schulze-Osthoff K, Lenz G, Hailfinger S.  Blood. 2020 Jan 9;135(2):121-132.(IF 16.601) [PubMed].     

The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression. Zhang C, Chen Z, Yin Q, Fu X, Li Y, Stopka T, Skoultchi AI, Zhang Y. Genes Dev. 2020 Jan 9. doi: 10.1101/gad.331157.119. (IF 8.998) [Pubmed] 

Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma. Prukova D, Andera L, Nahacka Z, Karolova J, Svaton M, Klanova M, Havranek O, Soukup J, Svobodova K, Zemanova Z, Tuskova D, Pokorna E, Helman K, Forsterova K, Pacheco-Blanco M, Vockova P, Berkova A, Fronkova E, Trneny M, Klener P.  Clin Cancer Res. 2019 Jul 15;25(14):4455-4465. doi: 10.1158/1078-0432.CCR-18-3275. (IF 10.199) [PubMed]    

A three-pronged "Pitchfork" strategy enables an extensive description of the human membrane proteome and the identification of missing proteins. Vit O, Harant K, Klener P, Man P, Petrak J.  J Proteomics. 2019 Jul 30;204:103411. doi: 10.1016/j.jprot.2019.103411. (IF 3.537) [PubMed]

Affinity depletion versus relative protein enrichment: a side-by-side comparison of two major strategies for increasing human cerebrospinal fluid proteome coverage. Jankovska E, Svitek M, Holada K, Petrak J. . Jankovska E, Svitek M, Holada K, Petrak J. Clin Proteom (2019) 16:9. https://doi.org/10.1186/s12014-019-9229-1.      (IF 3.516) [PubMed]

Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer. Kleiblova P, Stolarova L, Krizova K, Lhota F, Hojny J, Zemankova P, Havranek O, Vocka M, Cerna M, Lhotova K, Borecka M, Janatova M, Soukupova J, Sevcik J, Zimovjanova M, Kotlas J, Panczak A, Vesela K, Cervenkova J, Schneiderova M, Burocziova M, Burdova K, Stranecky V, Foretova L, Machackova E, Tavandzis S, Kmoch S, Macurek L, Kleibl Z.Int J Cancer. 2019 May 3. doi: 10.1002/ijc.32385.(IF 7.360) [PubMed] 

ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing b-selection. Zikmund T, Kokavec J, Turkova T, Savvulidi P, Paszekova H, Vodenkova S, Sedlacek R, Skoultchi AI, and Stopka T. J Immunol. 2019 Jun 15;202(12):3434-3446. doi: 10.4049/jimmunol.1801684. (IF 4.539) [PubMed]

Myocardial iron homeostasis and hepcidin expression in a rat model of heart failure at different levels of dietary iron intake. Petrak J, Havlenova T, Krijt M, Behounek M, Franekova J, Cervenka L, Pluhacek T, Vyoral D, Malenovsky V.  Biochim Biophys Acta Gen Subj. 2019 Jan 21. pii: S0304-4165(19)30016-9. doi: 10.1016/j.bbagen.2019.01.010. (IF 3.679) [PubMed]

Affinity depletion versus relative protein enrichment: a side-by-side comparison of two major strategies for increasing human cerebrospinal fluid proteome coverage. Jankovska E, Svitek M, Holada K, Petrak J. Clin Proteom (2019) 16:9. https://doi.org/10.1186/s12014-019-9229-1. (IF 3.516) [PDF]

 Azacitidine Switch to Lenalidomide Eradicated the TP53/ CDKN2A Co-Mutated Clone and Induced Long-Term Erythroid Response in Del(5q) MDS. Minarik L, Zemanova Z, Kulvait V, Dluhosova M, Jonasova A and Stopka T. Ann Hematol Oncol. 2019; 6(1): 0000. [PDF] (IF 2.219)

Rituximab maintenance significantly prolongs progression-free survival of patients with newly diagnosed mantle cell lymphoma treated with the Nordic MCL2 protocol and autologous stem cell transplantation. Klener P, Salek D, Pytlik R, Mocikova H, Forsterova K, Blahovcova P, Campr V, Prochazka V, Obr A, Jaksa R, Kuntscherova J, Boudová L, Kodet R, Janikova A, Trneny M. . Am J Hematol. 2018 Nov 25. doi: 10.1002/ajh.25362. [PubMed ] (IF 5.303)                                   

Skeletal Muscle Abnormalities and Iron Deficiency in Chronic Heart Failure(An Exercise 31P Magnetic Resonance Spectroscopy Study of Calf Muscle). Melenovsky V, Hlavata K, Sedivy P, Dezortova M, Borlaug BA, Petrak J, Kautzner J, Hajek M.  Circ Heart Fail. 2018 Sep;11(9):e004800. doi: 10.1161/CIRCHEARTFAILURE.117.004800. [PubMed] (IF5.684)                                                                                                     

Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using ⁵⁵Fe and storage phosphorimaging. Krijt M, Jirkovska A, Kabickova T, Melenovsky V, Petrak J, Vyoral D.  BBA-GEN SUBJECTS 1862 (2018) 2895-2901. https://doi.org/10.1016/j.bbagen.2018.09.005. [PubMed]  (IF 3.6790)    

Kidney Response to Heart Failure: Proteomic Analysis of Cardiorenal Syndrome. Melenovsky V, Cervenka L, Viklicky O, Franekova J, Havlenova T, Behounek M, Chmel M, Petrak J.  Kidney Blood Press Res. 2018;43(5):1437-1450. doi: 10.1159/000493657. [PubMed] (IF 3.000)                                                                                                                                                                                       

Potential loss of prognostic significance of minimal residual disease assessment after R-CHOP-based induction in elderly patients with mantle cell lymphoma in the era of rituximab maintenance. Klener P, Fronkova E, Kalinova M, Belada D, Forsterova K, Pytlik R, Blahovcova P, Simkovic M, Salek D, Mocikova H, Prochazka V, Janikova A, Vaskova M, Mejstrikova E, Kodet R, Trka J, Trneny M.  Hematol Oncol. 2018 Aug 20. doi: 10.1002/hon.2550. [PubMed] (IF 3.193)                                                                                                                                                                                                                                                                                                                                                     Alternating R-CHOP and R-cytarabine is a safe and effective regimen for transplant-ineligible patients with a newly diagnosed mantle cell lymphoma. Klener P, Fronkova E, Belada D, Forsterova K, Pytlik R, Kalinova M, Simkovic M, Salek D, Mocikova H, Prochazka V, Blahovcova P, Janikova A, Markova J, Obr A, Berkova A, Kubinyi J, Vaskova M, Mejstrikova E, Campr V, Jaksa R, Kodet R, Michalova K, Trka J, Trneny M.  Hematol Oncol. 2018 Feb;36(1):110-115. doi: 10.1002/hon.2483. [PubMed] (IF 3.193)

Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging. Etrych T, Daumová L, Pokorná E, Tušková D, Lidický O, Kolářová V, Pankrác J, Šefc L, Chytil P, Klener P.  J Control Release. 2018 Sep 22;289:44-55. doi: 10.1016/j.jconrel.2018.09.018. [PubMed] (IF 7.877)

Anaplastic Large-Cell Lymphoma Associated with Breast Implants: A Case Report of a Transgender Female. Patzelt M, Zarubova L, Klener P, Barta J, Benkova K, Brandejsova A, Trneny M, Gürlich R, Sukop A. Aesthetic Plast Surg. 2018 Apr;42(2):451-455. doi: 10.1007/s00266-017-1012-y. [PubMed] (IF 1.484) 

BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia. Srutova K, Curik N, Burda P, Savvulidi F, Silvestri G, Trotta R, Klamova H, Pecherkova P, Sovova Z, Koblihova J, Stopka T, Perrotti D, Machova Polakova K. Haematologica. 2018 Jul 26. pii: haematol.2018.193086. doi: 10.3324/haematol.2018.193086. [PubMed] (IF 9.09)

Lenalidomide treatment in lower risk myelodysplastic syndromes—The experience of a Czech hematology center. (Positive effect of erythropoietin±prednisone addition to lenalidomide in refractory or relapsed patients). Jonasova A, Neuwirtova R, Polackova H, Siskova M, Stopka T, Cmunt E, Belickova M, Moudra A, Minarik L, Fuchs O, Michalova K, Zemanova Z. Leukemia Research 69 (2018) 12-17. 2018 March 27. https://doi.org/10.1016/j.leukres.2018.03.015 . [PDF] (IF 2.501)

Somatic mutation dynamics in MDS patients treated with azacitidine indicate clonal selection in patients-responders. Polgarova K, Vargova K, Kulvait V, Dusilkova N, Minarik L, Zemanova Z, Pesta M, Jonasova A and Stopka T. Oncotarget. 2017 Dec 6. [PDF] (IF 5.168)

 Plasma miR-155, miR-203, and miR-205 are Biomarkers for Monitoring of Primary Cutaneous T-cell Lymphomas. Dusilkova N, Basova P, Polivka J, Kodet O, Kulvait V, Pesta M, Trneny M, Stopka T. Int J Mol Sci. 2017 Oct 15;18(10). pii: E2136. doi: 10.3390/ijms18102136. [PDF] (IF: 3.226)

Hematopoiesis in patients with mature B-cell malignancies is deregulated even in patients with undetectable bone marrow involvement. Maswabi BC, Molinsky J, Savvulidi F, Zikmund T, Prukova D, Tuskova D, Klanova M, Vockova P, Lateckova L, Sefc L, Zivny J, Trneny M, Klener P.  Haematologica. 2017 Apr;102(4):e152-e155. doi: 10.3324/haematol.2016.151571. [PubMed] (IF 7.702)

The ISWI ATPase Smarca (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells. Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T. Stem Cells. 2017 Mar 9. doi: 10.1002/stem.2604. [PubMed] (5-year IF 6.872)

MiR-155/miR-150 network regulates progression through the disease phases of chronic lymphocytic leukemia.Vargova K, Pesta M, Obrtlikova P, Dusilkova N, Minarik L, Vargova J, Berkova A, Zemanova Z, Michalova K, Spacek M, Trneny M, Stopka T. Blood Cancer J. 2017 Jul 21;7(7):e585. doi: 10.1038/bcj.2017.63. [PDF] (IF 6.126)

Mantle cell lymphoma-variant Richter syndrome: Detailed molecular-cytogenetic and backtracking analysis reveals slow evolution of a pre-MCL clone in parallel with CLL over several years. Klener P, Fronkova E, Berkova A, Jaksa R, Lhotska H, Forsterova K, Soukup J, Kulvait V, Vargova J, Fiser K, Prukova D, Alam M, Calvin Lenyeletse Maswabi B, Michalova K, Zemanova Z, Jancuskova T, Pekova S, Trneny M.  Int J Cancer. 2016 Nov 15;139(10):2252-60. doi: 10.1002/ijc.30263. [PubMed] (IF 6.513)

Differential Expression, Localization and Activity of MARCKS between Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia. Vargova J, Vargova K, Dusilkova N, Kulvait V, Pospisil V, Zavadil J, Trneny M, Klener P, Stopka T. Blood Cancer J. 2016 Sep 23;6(9):e475. doi: 10.1038/bcj.2016.80. [PDF] (IF 4.411)

Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, Prukova D, Vejmelkova D, Jaksa R, Helman K, Vockova P, Lateckova L, Molinsky J, Maswabi BC, Alam M, Kodet R, Pytlik R, Trneny M, Klener P.  Clin Cancer Res. 2016 Mar 1;22(5):1138-49. doi: 10.1158/1078-0432.CCR-15-1191. [PubMed] (IF 9.619)

GATA-1 inhibits PU.1 gene via DNA and histone H3K9 Methylation of its Distal Enhancer in Erythroleukemia. Burda P, Vargova J, Curik N, Salek C, Papadopoulos GL, Strouboulis J, Stopka T. PLoS One, 2016 Mar 24;11(3):e0152234 [PDF] (IF 3.234)

Distinct and overlapping DNMT1 interactions with multiple transcription factors in erythroid cells: evidence for co-repressor functions. Papageorgiou DN, Karkoulia E, Amaral-Psarris A, Burda P, Kolodziej K, Demmers J, Bungert J, Stopka T, Strouboulis J. Biochim Biophys Acta. 2016 Dec;1859(12):1515-1526. doi: 10.1016/j.bbagrm.2016.09.007. [PDF] (IF: 5.373)

Basova P, Pospisil V, Savvulidi F, Burda P, Vargova K, Stanek L, Dluhosova M, Kuzmova E, Jonasova A, Steidl U, Laslo P, Stopka T. Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice. Oncogene. 2014 Sep 25;33(39):4735-45. doi: 10.1038/onc.2013.414. [PubMed] (IF: 8.459)

For the year 2013/2014 the Scientia Foundation Award has been awarded to Petra Bašová PhD & Karina Vargová PhD, two postdoctoral fellows in our laboratory, for outstanding research publications and PhD theses.

Klanova M, Andera L, Soukup J, Svadlenka J, Benesova S, Brazina J, Prukova D, Vejmelkova D, Jaksa R, Helman K, Vockova P, Lateckova L, Molinksy J, Maswabi B, Alam M, Kodet R, Pytlík R, Trneny M, Klener P Jr. Targeting of BCL2 family proteins with ABT-199 and homoharringtonine reveals BCL2- and MCL1-dependent subgroups of diffuse large B-cell lymphoma. Clin Cancer Res. 2015 Oct 14. pii: clincanres.1191.2015. (IF 8.722)

Lorkova L, Scigelova M, Arrey TN, Vit O, Pospisilova J, Doktorova E, Klanova M, Alam M, Vockova P, Maswabi B, Klener P Jr, Petrak J. Detailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma Cells. PLoS One. 2015 Aug 18;10(8):e0135314. doi:10.1371/journal.pone.0135314. eCollection 2015. (IF 3.234)

Klener P Jr, Otáhal P, Lateckova L, Klener P. Immunotherapy Approaches in Cancer Treatment. Curr Pharm Biotechnol. 2015;16(9):771-81. (IF 2.51)

H. Huskova, K. Korecka, J. Karban, K. Vargova, J. Vargova, N. Dusilkova, M. Trneny, and T. Stopka. Oncogenic microRNA-155 and its target PU.1: An integrative gene expression study in six of the most prevalent lymphomas. International Journal of Hematology, Int J Hematol. 2015 Oct;102(4):441-50. doi: 10.1007/s12185-015-1847-4. Epub 2015 Aug 11. (IF 1.918)

K. Machova Polakova, V. Kulvait, Adela Benesova, J. Linhartova, H. Klamova, M. Jaruskova, C. de Benedittis, T. Haferlach, M. Baccarani, G. Martinelli, T. Stopka, T. Ernst, A. Hochhaus, A. Kohlmann, and S. Soverini. Next generation deep-sequencing improves detection of BCR-ABL1 kinase domain mutations emerging under tyrosine kinase inhibitor treatment of chronic myeloid leukemia patients in chronic phase. J Cancer Res Clin Oncol. 2015 May;141(5):887-99. doi: 10.1007/s00432-014-1845-6. (IF 3.01)

Bolzano award is given annually by Charles University in Prague and represents one of most prestigious University Awards dedicated for successful postdoctoral fellows.

_{Bernard Bolzano (1781-1848)}

_{Ceremony: Thursday January 31st 2013 at 1 p.m., Malá aula Karolina Univerzity Karlovy v Praze, Ovocný trh 3, Praha 1, 1st floor}

_{Ceremony report:} link

(see in czech)

http://cuni.cz/IFORUM-14022.html

http://iforum.cuni.cz/IFORUM-14024.html

http://www.cuni.cz/UK-381.html

http://www.lf1.cuni.cz/prestizni-bolzanovu-cenu-obdrzeli-tri-mladi-talentovani-vedci