Vybrané úspěchy
Souhrnný přehled nejvýznamnějších publikačních výstupů:
Tkachenko A, Onishchenko A, Myasoedov V, Yefimova S, Havranek O. Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review. Nanotoxicology. 2023 Apr 21:1-31. doi: 10.1080/17435390.2023.2203239. (IF 5.0) [PubMed]
Vit O, Talacko P, Musil Z, Hartmann I, Pacak K, Petrak J. Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization. Clin Proteom 20, 39 (2023). https://doi.org/10.1186/s12014-023-09428-7 (IF 3.8) [Link]
Benes J, Kroupova K, Kotrc M, Petrak J, Jarolim P, Novosadova V, Kautzner J, Melenovsky V. FGF-23 is a biomarker of RV dysfunction and congestion in patients with HFrEF. Sci Rep. 2023 Sep 25;13(1):16004. doi: 10.1038/s41598-023-42558-4. (IF 18.2) [Pubmed]
Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr., Paces J, Skoultchi AI, Stopka T, Kozmik Z.Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Cells. 2023; 12(7):1035. https://doi.org/10.3390/cells12071035 (IF 6.0) [PubMeb]
Knizkova D, Pribikova M, Draberova H, Semberova T, Trivic T, Synackova A, Ujevic A, Stefanovic J, Drobek A, Huranova M, Niederlova V, Tsyklauri O, Neuwirth A, Tureckova J, Stepanek O, Draber P. CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology. K Nat Immunol. 2022 Oct 21. doi: 10.1038/s41590-022-01325-9. (IF 30.5) [PubMed]
Jankovska E, Lipcseyova D, Svrdlikova M, Pavelcova M, Kubala Havrdova E, Holada K, Petrak J. Quantitative proteomic analysis of cerebrospinal fluid of women newly diagnosed with multiple sclerosis. Int J Neurosci. 2022 Jul;132(7):724-734. doi: 10.1080/00207454.2020.1837801. (IF 2.590) [PubMed]
Maco M, Kupcova K, Herman V, Ondeckova I, Kozak T, Mocikova H, Havranek O; Czech Hodgkin Lymphoma Study Group. Circulating tumor DNA in Hodgkin lymphoma. Ann Hematol. 2022 Nov;101(11):2393-2403. doi: 10.1007/s00277-022-04949-x. (IF 4.03) [PubMed]
Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P. Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2022 Jan;21(1):89-99. doi: 10.1158/1535-7163.MCT-21-0511.(IF 6.261) [PubMed]
Stopka T, Minařík L, Dusilková N, Pešta M, Kulvait V, Špaček M, Zemanová Z, Kalousová M, Jonášová A. G-CSF plus azacitidine versus azacitidine alone for patients with high-risk myelodysplastic syndrome: academic, open label, randomized trial. . Blood Cancer J. 2022 Jul 7;12(7):105. doi: 10.1038/s41408-022-00698-2. (IF 11.98) [link]
Bašová P, Paszeková H, Minařík L, Dluhošová M, Burda P, Stopka T. Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents. Int J Mol Sci. 2022 Jun 16;23(12):6729. doi: 10.3390/ijms23126729. (IF 5.9) [PubMed]
Krsmanovic P, Mocikova H, Chramostova K, Klanova M, Trnkova M, Pesta M, Laslo P, Pytlik R, Stopka T, Trneny M, Pospisil V. Circulating microRNAs in Cerebrospinal Fluid and Plasma: Sensitive Tool for Detection of Secondary CNS Involvement, Monitoring of Therapy and Prediction of CNS Relapse in Aggressive B-NHL Lymphomas. Cancers. 2022; 14(9):2305. https://doi.org/10.3390/cancers14092305. (Web) IF = 6.6
Thakur S, Cahais V, Turkova T, Zikmund T, Renard C, Stopka T, Korenjak M, Zavadil J.Chromatin Remodeler Smarca5 Is Required for Cancer-Related Processes of Primary Cell Fitness and Immortalization. Cells 2022, 11,808. https://doi.org/10.3390/cells11050808. (PubMed) IF = 6.6
Minařík L, Pimková K, Kokavec J, Schaffartziková A, Vellieux F, Kulvait V, Daumová L, Dusilková N, Jonášová A, Vargová KS, Králová Viziová P, Sedláček R, Zemanová Z, Stopka T. Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways. Cells. 2022; 11(2):223. https://doi.org/10.3390/cells11020223. (PubMed) IF = 6.6
Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P. Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2022 Jan;21(1):89-99. doi: 10.1158/1535-7163.MCT-21-0511. Epub 2021 Nov 2. [PubMed] IF = 6.3
Vit O, Patel M, Musil Z, Hartmann I, Frysak Z, Miettinen M, Pacak K and Petrak J. Deep Membrane Proteome Profiling Reveals Overexpression of Prostate-Specific Membrane Antigen (PSMA) in High-Risk Human Paraganglioma and Pheochromocytoma, Suggesting New Theranostic Opportunity. Molecules 2021, 26, 6567. (PubMed) IF = 4.412
Hrdinova T, Toman O, Dresler J, Klimentova J, Salovska B, Pajer P, Bartos O, Polivkova V, Linhartova J, Machova Polakova K, Kabickova H, Brodska B, Krijt M, Zivny J, Vyoral D and Petrak J. Exosomes released by imatinib-resistant K562 cells contain specific membrane markers, IFITM3, CD146 and CD36 and increase the survival of imatinib-sensitive cells in the presence of imatinib. Int. J. Oncol. 58: 238-250, 2021. (Pubmed) IF = 3.899
Havlenova T, Skaroupkova P, Miklovic M, Behounek M, Chmel M, Jarkovska D, Sviglerova J, Stengl M, Kolar M, Novotny J, Benes J, Cervenka L, Petrak J, Melenovsky V. Right versus left ventricular remodeling in heart failure due to chronic volume overload. Sci Rep. 2021 Aug 24;11(1):17136. doi: 10.1038/s41598-021-96618-8. (PubMed) IF = 4.379
Szydłowski M, Garbicz F, Jabłońska E, Górniak P, Komar D, Pyrzyńska B, Bojarczuk K, Prochorec-Sobieszek M, Szumera-Ciećkiewicz A, Rymkiewicz G, Cybulska M, Statkiewicz M, Gajewska M, Mikula M, Gołas A, Domagała J, Winiarska M, Graczyk-Jarzynka A, Białopiotrowicz E, Polak A, Barankiewicz J, Puła B, Pawlak M, Nowis D, Golab J, Tomirotti AM, Brzózka K, Pacheco-Blanco M, Kupcova K, Green MR, Havranek O, Chapuy B, Juszczyński P. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20. Antibodies. Cancer Res. 2021 Dec 1;81(23):6029-6043. doi: 10.1158/0008-5472.CAN-21-1023. [PubMed] IF = 12.7
Vockova P, Molinsky J, Klanova M, Karban J, Spacek M, Havranek O, Kupcova K, Kazantsev D, Trneny M, Klener P. CD31/PECAM-1 impacts engraftment, growth and spread of mantle cell lymphoma cells and positively correlates with extramedullary involvement. Leuk Lymphoma. 2021 Apr;62(4):861-867. doi: 10.1080/10428194.2020.1849678. [PubMed] IF= 2969
Henderson J, Havranek O, Ma MCJ, Herman V, Kupcova K, Chrbolkova T, Pacheco-Blanco M, Wang Z, Comer JM, Zal T, Davis RE. Detecting Förster resonance energy transfer in living cells by conventional and spectral flow cytometry. Cytometry A. 2021 Jun 14. doi: 10.1002/cyto.a.24472. [PubMed] IF = 4.355
Pola R, Pokorná E, Vočková P, Böhmová E, Pechar M, Karolová J, Pankrác J, Šefc L, Helman K, Trněný M, Etrych T, Klener P. Cytarabine nanotherapeutics with increased stability and enhanced lymphoma uptake for tailored highly effective therapy of mantle cell lymphoma. Acta Biomater. 2021 Jan 1;119:349-359. doi: 10.1016/j.actbio.2020.11.014. IF = 10.633
Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes. Pribyl M, Hubackova S, Moudra A, Vancurova M, Polackova H, Stopka T, Jonasova A, Bokorova R, Fuchs O, Stritesky J, Salovska B, Bartek J, Hodny Z. [published online ahead of print, 2020 Jul 21]. Mol Oncol. 2020;10.1002/1878-0261.12768. doi:10.1002/1878-0261.12768. [PubMed] IF = 6.574
Jankovska E, Lipcseyova D, Svrdlikova M, Pavelcova M, Kubala Havrdova E, Holada K, Petrak J. Quantitative proteomic analysis of cerebrospinal fluid of women newly diagnosed with multiple sclerosis. Int J Neurosci. 2020 Oct 29:1-11. doi: 10.1080/00207454.2020.1837801. [PubMed] IF = 2.107
Jain N, Singh S, Laliotis G, Hart A, Muhowski E, Kupcova K, Chrbolkova T, Khashab T, Chowhury SM, Sircar A, Shirazi F, Singh RK, Alinari L, Zhu J, Havranek O, Tsichlis P, Woyach J, Baiocchi R, Samaniego F, Sehgal L.Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma. Blood Adv. 2020;4(18):4382-4392. doi:10.1182/bloodadvances.2020001685. [Pubmed] IF = 4.584
Draberova H, Janusova S, Knizkova D, Semberova T, Pribikova M, Ujevic A, Harant K, Knapkova S, Hrdinka M, Fanfani V, Stracquadanio G, Drobek A, Ruppova K, Stepanek O, Draber Peter. Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop. EMBO J. 2020 Sep 1;39(17):e104202. doi:10.15252/embj.2019104202. [PubMed] IF = 9.889
Zikmund T, Paszekova H, Kokavec J, Kerbs P, Thakur S, Turkova T, Tauchmanova P, Greif PA, Stopka T. Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion. Int J Mol Sci. 2020;21(6):E2073. Published 2020 Mar 18. doi:10.3390/ijms21062073. [PubMeb] IF = 4.183;
Zhang C, Chen Z, Yin Q, Fu X, Li Y, Stopka T, Skoultchi AI, Zhang Y. The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression. Genes Dev. 2020 Jan 9. doi: 10.1101/gad.331157.119. [PubMed] IF = 8.998
Bucher P, Erdmann T, Grondona P, Xu W, Schmitt A, Schürch C, Zapukhlyak M, Schönfeld C, Serfling E, Kramer D, Grau M, Klener P, Lengerke C, Schulze-Osthoff K, Lenz G, Hailfinger S. Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma. Blood. 2020 Jan 9;135(2):121-132. doi: 10.1182/blood.2019001866. IF = 23.629
Klanova M, Klener P. BCL-2 Proteins in Pathogenesis and Therapy of B-Cell Non-Hodgkin Lymphomas. Cancers (Basel). 2020 Apr 10;12(4):938. doi: 10.3390/cancers12040938. IF = 6.639
Lemm EA, Valle-Argos B, Smith LD, Richter J, Gebreselassie Y, Carter MJ, Karolova J, Svaton M, Helman K, Weston-Bell NJ, Karydis L, Williamson CT, Lenz G, Pettigrew J, Harwig C, Stevenson FK, Cragg M, Forconi F, Steele AJ, Cross J, Mackenzie L, Klener P, Packham G. Preclinical evaluation of a novel SHIP1 phosphatase activator for inhibition of PI3K signaling in malignant B-cells. Clin Cancer Res. 2019 Dec 12. pii: clincanres.2202.2019. doi: 10.1158/1078-0432.CCR-19-2202. IF = 8.911
ZIKMUND, Tomáš - KOKAVEC, Juraj - TURKOVÁ, Tereza - SAVVULIDI, Filipp Georgievič - PASZEKOVÁ, Helena - VODENKOVÁ, Soňa - SEDLÁČEK, Radislav - SKOULTCHI, Arthur I. - STOPKA, Tomáš. ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection. The Journal of Immunology. 2019, 202(12), 3434-3446. ISSN 0022-1767. DOI: 10.4049/jimmunol.1801684 IF = 4.718
JANKOVSKÁ, Eliška - SVÍTEK, Marek - HOLADA, Karel - PETRÁK, Jiří. Affinity depletion versus relative protein enrichment: a side-by-side comparison of two major strategies for increasing human cerebrospinal fluid proteome coverage. Clinical Proteomics. 2019, 16(February), nestránkováno. ISSN 1542-6416. DOI: 10.1186/s12014-019-9229-1 IF = 2.892
PRŮKOVÁ, Dana - ANDERA, Ladislav - NAHACKA, Zuzana - KAROLOVÁ, Jana - SVATOŇ, Michael - ZIKMUNDOVÁ, Magdalena - HAVRÁNEK, Ondřej - SOUKUP, Jan - SVOBODOVÁ, Karla - ZEMANOVÁ, Zuzana - TUŠKOVÁ, Diana - POKORNÁ, Eva - HELMAN, Karel - FORSTEROVÁ, Kristina - PACHECO-BLANCO, Mariana - VOČKOVÁ, Petra - BERKOVÁ, Adéla - FROŇKOVÁ, Eva - TRNĚNÝ, Marek - KLENER, Pavel. Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma. Clinical Cancer Research. 2019, 25(14), 4455-4465. ISSN 1078-0432. DOI: 10.1158/1078-0432.CCR-18-3275 IF = 8.911
PETRÁK, Jiří - HAVLENOVA, Tereza - KRIJT, Matyáš - BĚHOUNEK, Matěj - FRANEKOVA, Janka - CERVENKA, Ludek - PLUHACEK, Tomas - VYORAL, Daniel - MELENOVSKY, Vojtech. Myocardial iron homeostasis and hepcidin expression in a rat model of heart failure at different levels of dietary iron intake. Biochimica et Biophysica Acta - General Subjects. 2019, 1863(4), 703-713. ISSN 0304-4165. DOI: 10.1016/j.bbagen.2019.01.010 IF = 3.681
VÍT, Ondřej - HARANT, Karel - KLENER, Pavel - MAN, Petr - PETRÁK, Jiří. A three-pronged "Pitchfork" strategy enables an extensive description of the human membrane proteome and the identification of missing proteins. Journal of Proteomics. 2019, 204(July), nestránkováno. ISSN 1874-3919. DOI: 10.1016/j.jprot.2019.103411 IF = 3.537
KLENER, Pavel - ETRYCH, Tomáš - KLENER, Pavel. Biological Therapy of Hematologic Malignancies: Toward a Chemotherapy-free Era. Current Medicinal Chemistry. 2019, 26(6), 1002-1018. ISSN 0929-8673. DOI: 10.2174/0929867324666171006144725 IF = 3.894
JORDA, Radek - HAVLÍČEK, Libor - ŠTURC, Antonín - TUŠKOVÁ, Diana - DAUMOVÁ, Lenka - ALAM, Mahmudul - ŠKERLOVÁ, Jana - NEKARDOVÁ, Michaela - PEŘINA, Miroslav - POSPÍŠIL, Tomáš - ŠIROKÁ, Jitka - URBÁNEK, Lubor - PACHL, Petr - ŘEZÁČOVÁ, Pavlína - STRNAD, Miroslav - KLENER, Pavel - KRYŠTOF, Vladimír. 3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models. Journal of Medicinal Chemistry. 2019, 62(9), 4606-4623. ISSN 0022-2623. DOI: 10.1021/acs.jmedchem.9b00189 IF = 6.054
MCKENZIE, Mark D - GHISI, Margherita - OXLEY, Ethan P - NGO, Steven - CIMMINO, Luisa - ESNAULT, Cecile - LIU, Ruijie - SALMON, Jessica M - BELL, Charles C - AHMED, Nouraiz - ERLICHSTER, Michael - WITKOWSKI, Matthew T - LIU, Grace J - CHOPIN, Michael - DAKIC, Aleksandar - SIMANKOWICZ, Emilia - POMILIO, Giovanna - VU, Tina - KRSMANOVIĆ, Pavle - SU, Shian - TIAN, Luyi - BALDWIN, Tracey M - ZALCENSTEIN, Daniela A - DIRAGO, Ladina - WANG, Shu - METCALF, Donald - JOHNSTONE, Ricky W - CROKER, Ben A - LANCASTER, Graeme I - MURPHY, Andrew J - NAIK, Shalin H - NUTT, Stephen L - POSPÍŠIL, Vít - SCHROEDER, Timm - WALL, Meaghan - DAWSON, Mark A - WEI, Andrew H - DE THE, Hugues - RITCHIE, Matthew E - ZUBER, Johannes - DICKINS, Ross A. Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia. Cell Stem Cell. 2019, 25(2), 258-272.e9. ISSN 1934-5909. DOI: 10.1016/j.stem.2019.07.001 IF = 21.464
KLEIBLOVÁ, Petra - STOLAŘOVÁ, Lenka - KRIZOVA, Katerina - LHOTA, Filip - HOJNÝ, Jan - ZEMÁNKOVÁ, Petra - HAVRÁNEK, Ondřej - VOČKA, Michal - ČERNÁ, Marta - LHOTOVÁ, Klára - BORECKÁ, Marianna - JANATOVÁ, Markéta - SOUKUPOVÁ, Jana - ŠEVČÍK, Jan - ZIMOVJANOVÁ, Martina - KOTLAS, Jaroslav - PANCZAK, Aleš - VESELÁ, Kamila - ČERVENKOVÁ, Jana - SCHNEIDEROVÁ, Michaela - BUROCZIOVA, Monika - BURDOVA, Kamila - STRÁNECKÝ, Viktor - FORETOVA, Lenka - MACHACKOVA, Eva - TAVANDZIS, Spiros - KMOCH, Stanislav - MACUREK, Libor - KLEIBL, Zdeněk. Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer. International Journal of Cancer. 2019, 145(7), 1782-1797. ISSN 0020-7136. DOI: 10.1002/ijc.32385 IF = 4.982
KLENER, Pavel. Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma. International Journal of Molecular Sciences [online]. 2019, 20(18), nestránkováno. ISSN 1422-0067. DOI: 10.3390/ijms20184417 IF = 4.183 (2018)
KLEIBLOVÁ, Petra - STOLAŘOVÁ, Lenka - KŘÍŽOVÁ, Kateřina - LHOTA, Filip - HOJNÝ, Jan - ZEMÁNKOVÁ, Petra - HAVRÁNEK, Ondřej - VOČKA, Michal - ČERNÁ, Marta - LHOTOVÁ, Klára - BORECKÁ, Marianna - JANATOVÁ, Markéta - SOUKUPOVÁ, Jana - ŠEVČÍK, Jan - ZIMOVJANOVÁ, Martina - KOTLAS, Jaroslav - PANCZAK, Aleš - VESELÁ, Kamila - ČERVENKOVÁ, Jana - SCHNEIDEROVÁ, Michaela - BURÓCZIOVÁ, Monika - BURDOVÁ, Kamila - STRÁNECKÝ, Viktor - FORETOVÁ, Lenka - MACHÁČKOVÁ, Monika - TAVANDZIS, Spiros - KMOCH, Stanislav - MACŮREK, Libor - KLEIBL, Zdeněk. Dědičné mutace v genu CHEK2 jako příčina dispozice k nádorům prsu - typy mutací, jejich biologická a klinická relevance. Klinická onkologie. 2019, 32(Suppl 2), 2S36-2S50. ISSN 0862-495X. DOI: 10.14735/amko2019S36
JONÁŠOVÁ, Anna - NEUWIRTOVÁ, Radana - POLÁČKOVÁ, Helena - ŠIŠKOVÁ, Magda - STOPKA, Tomáš - CMUNT, Eduard - BELICKOVA, Monika - MOUDRA, Alena - MINAŘÍK, Ľubomír - FUCHS, Ota - MICHALOVÁ, Kyra - ZEMANOVÁ, Zuzana. Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin +/- prednisone addition to lenalidomide in refractory or relapsed patients). Leukemia Research. 2018, 69(June), 12-17. ISSN 0145-2126. DOI: 10.1016/j.leukres.2018.03.015 IF = 2.066 (2018)
KLENER, Pavel - FROŇKOVÁ, Eva - KALINOVÁ, Markéta - BELADA, David - FORSTEROVÁ, Kristina - PYTLÍK, Robert - BLAHOVCOVÁ, Petra - ŠIMKOVIČ, Martin - SALEK, David - MÓCIKOVÁ, Heidi - PROCHAZKA, Vit - JANIKOVA, Andrea - VÁŠKOVÁ, Martina - MEJSTŘÍKOVÁ, Ester - KODET, Roman - TRKA, Jan - TRNĚNÝ, Marek. Potential loss of prognostic significance of minimal residual disease assessment after R-CHOP-based induction in elderly patients with mantle cell lymphoma in the era of rituximab maintenance. Hematological Oncology. 2018, 36(5), 773-778. ISSN 0278-0232. DOI: 10.1002/hon.2550 IF = 3.439 (2018)
ETRYCH, Tomáš - DAUMOVÁ, Lenka - POKORNÁ, Eva - TUŠKOVÁ, Diana - LIDICKÝ, Ondřej - KOLÁŘOVÁ, Věra - PANKRÁC, Jan - ŠEFC, Luděk - CHYTIL, Petr - KLENER, Pavel. Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging. Journal of Controlled Release. 2018, 289(November), 44-55. ISSN 0168-3659. DOI: 10.1016/j.jconrel.2018.09.018 IF = 7.901 (2018)
KRIJT, Matyáš - JIRKOVSKÁ, Anna - KABÍČKOVÁ, Tereza - MELENOVSKÝ, Vojtěch - PETRÁK, Jiří - VYORAL, Daniel. Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using Fe-55 and storage phosphorimaging. Biochimica et Biophysica Acta - General Subjects. 2018, 1862(12), 2895-2901. ISSN 0304-4165. DOI: 10.1016/j.bbagen.2018.09.005 IF = 3.681 (2018)
KLENER, Pavel - ŠÁLEK, David - PYTLÍK, Robert - MÓCIKOVÁ, Heidi - FORSTEROVÁ, Kristina - BLAHOVCOVÁ, Petra - CAMPR, Vít - PROCHÁZKA, Vít - OBR, Aleš - JAKŠA, Radek - KUNTSCHEROVÁ, Jana - BOUDOVÁ, Ludmila - KODET, Roman - JANÍKOVÁ, Andrea - TRNĚNÝ, Marek. Rituximab maintenance significantly prolongs progression-free survival of patients with newly diagnosed mantle cell lymphoma treated with the Nordic MCL2 protocol and autologous stem cell transplantation. American Journal of Hematology. 2019, 94(2), e50-e53. ISSN 0361-8609. DOI: 10.1002/ajh.25362 IF = 6.137 (2018)
ŠRŮTOVÁ, Klára - ČUŘÍK, Nikola - BURDA, Pavel - SAVVULIDI, Filipp - SILVESTRI, Giovannino - TROTTA, Rossana - KLAMOVÁ, Hana - PECHERKOVA, Pavla - SOVOVA, Zofie - KOBLIHOVA, Jitka - STOPKA, Tomáš - PERROTTI, Danilo - MACHOVÁ POLÁKOVÁ, Kateřina. BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia. Haematologica. 2018, 103(12), 2016-2025. ISSN 0390-6078. DOI: 10.3324/haematol.2018.193086 IF = 7.570 (2018)
MELENOVSKY, Vojtech - HLAVATA, Katerina - SEDIVY, Petr - DEZORTOVA, Monika - BORLAUG, Barry A. - PETRÁK, Jiří - KAUTZNER, Josef - HAJEK, Milan. Skeletal Muscle Abnormalities and Iron Deficiency in Chronic Heart Failure : An Exercise 31P Magnetic Resonance Spectroscopy Study of Calf Muscle. Circulation: Heart Failure. 2018, 11(9), nestránkováno. ISSN 1941-3289. DOI: 10.1161/CIRCHEARTFAILURE.117.004800 IF = 6.526 (2018)MELENOVSKY, Vojtech - CERVENKA, Ludek - VIKLICKY, Ondrej - FRANEKOVA, Janka - HAVLENOVA, Tereza - BĚHOUNEK, Matěj - CHMEL, Martin - PETRÁK, Jiří. Kidney Response to Heart Failure: Proteomic Analysis of Cardiorenal Syndrome. Kidney & Blood Pressure Research. 2018, 43(5), 1437-1450. ISSN 1420-4096. DOI: 10.1159/000493657 IF = 2.123 (2018)
Souhrnný přehled 10 nejvýznamnějších publikačních výstupů v letech 2014 - 2017:
Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ. Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation. Nat Commun.2014 Jun 20;5:4181. (IF12.001), popisuje vytvoření a studium transgenních myších modelů, jež vedly k objasnění chromatinové regulace v kmenových buňkách mozku; spolupráce CZ-CAN-USA
Basova P, Pospisil V, Savvulidi F, Burda P, Vargova K, Stanek L, Dluhosova M, Kuzmova E, Jonasova A, Steidl U, Laslo P, Stopka T. Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice. Oncogene. 2014 Sep 25;33(39):4735-45. doi: 10.1038/onc.2013.414. (IF 7.632), popisuje vytvoření unikátního modelu leukemie v myši; spolupráce CZ-USA-UK
KLANOVA, Magdalena, LORKOVA, Lucie, VIT Ondrej, MASWABI, Bokang, MOLINSKY, Jan, POSPISILOVA, Jana, MAVIS, Cory, LATECKOVA, Lucie, KULVAIT, Vojtech, VEJMELKOVA, Dana, JAKSA, Radek, HERNANDEZ-ILIZARITURRI, Francisco, TRNENY, Marek, VOKURKA, Martin, PETRAK, Jiri, KLENER, Pavel. Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents. Mol Cancer, 2014, Jun 27;13:159. doi: 10.1186/1476-4598-13-159. (IF5.780), práce popisující mechanizmy lékové rezistence u agresivních lymfomů; spolupráce 1.LF+ VFN.
Pavel Otáhal, Dana Průková, Vlastimil Král, Milan Fabry, Lucie Latečková, Marek Trněný & Pavel Klener. Lenalidomide enhances anti-tumor functions of Chimeric Antigen Receptor modified T-cells. OncoImmunology. 2015, DOI: 10.1080/2162402X.2015.1115940. (IF 6.885), popisuje mechanizmus nových léků v imunoterapii lymfomů; spolupráce mezi 1.LF a VFN.
Klanova M, Andera L, Soukup J, Svadlenka J, Benesova S, Brazina J, Prukova D, Vejmelkova D, Jaksa R, Helman K, Vockova P, Lateckova L, Molinsky J, Maswabi B, Alam M, Kodet R, Pytlík R, Trneny M, Klener P Jr. Targeting of BCL2 family proteins with ABT-199 and homoharringtonine reveals BCL2- and MCL1-dependent subgroups of diffuse large B-cell lymphoma. Clin Cancer Res. 2015 Oct 14. pii: clincanres.1191.2015. (IF 8.751), jedná se o jednu z kolekce prací studující terapeutické možnosti lymfomů; spolupráce mezi 1.LF a VFN.
Shuying He, Saima Limi, Rebecca S. McGreal, Qing Xie, Lisa A. Brennan, Wanda Lee Kantorow, Juraj Kokavec, Romit Majumdar, Harry Hou, Jr, Winfried Edelmann, Wei Liu, Ruth Ashery-Padan, Jiri Zavadil, Marc Kantorow, Arthur Skoultchi, Tomas Stopka, and Ales Cvekl. Chromatin remodeling enzyme Snf2h/Smarca5 regulates embryonic lens differentiation and denucleation. Development. 2016 Jun 1;143(11):1937-47. doi: 10.1242/dev.135285. (IF 6.231), popisuje využití myších modelů ke studiu epigenetických mechanizmů v průběhu vývoje čočky z očních kmenových buněk; spolupráce CZ-USA
Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Filipp Savvulidi, Tomas Zikmund, Dana Prukova, Diana Tuskova, Magdalena Klanova, Petra Vockova, Lucie Lateckova, Ludek Sefc, Jan Zivny, Marek Trneny, and Pavel Klener. Hematopoiesis in patients with mature B cell malignancies is deregulated even in patients with undetectable bone marrow involvement. Haematologica. 2016; 101:xxx, doi:10.3324/haematol.2016.151571 Published Ahead of Print on January 5, 2017. (IF5.877), práce o patogenezi lymfomů spolupráce 1.LF+ VFN.
Pavel Klener, Eva Fronkova, Adela Berkova, Radek Jaksa, Halka Lhotska, Kristina Forsterova, Jan Soukup, Vojtech Kulvait, Jarmila Vargova, Karel Fiser, Dana Prukova, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Kyra Michalova, Zuzana Zemanova, Tereza Jancuskova, Sona Pekova and Marek Trneny. Mantle cell lymphoma-variant Richter syndrome: Detailed molecular-cytogenetic and backtracking analysis reveals slow evolution of a pre-MCL clone in parallel with CLL over several years. Int. J. Cancer. 2016, 139, 2252–2260. (IF 5.624), práce o patogenezi lymfomů, spolupráce mezi 1.LF a 2.LF UK.
Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T. The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells. Stem Cells. 2017 Jun;35(6):1614-1623. doi: 10.1002/stem.2604. (IF 6.281), popisuje využití myších modelů ke studiu normálních kmenových buněk krvetvorby; spolupráce CZ-USA
Maswabi BC, Molinsky J, Savvulidi F, Zikmund T, Prukova D, Tuskova D, Klanova M, Vockova P, Lateckova L, Sefc L, Zivny J, Trneny M, Klener P. Hematopoiesis in patients with mature B-cell malignancies is deregulated even in patients with undetectable bone marrow involvement. Haematologica. 2017 Apr;102(4):e152-e155. doi: 10.3324/haematol.2016.151571. (IF 6.372)
: celkový počet = 7
Bakalářské práce (3)
Tereza Turková
Název: SWI2/SNF2 ATPázy se zaměřením na podrodinu ISWI: proteinové komplexy a myší modely pro jejich studium. Katedra a fakulta: Molekulární biologie a biochemie organismů, PřF, UK, 2014. Vedoucí práce: Prof. Stopka
Marko Tichý
Název: Mechanismy a regulace liniové determinace v hematopoetické kmenové buňce. Katedra a fakulta: Buněčná biologie, PřF, UK, 2016. Vedoucí práce: Prof. Stopka
Petra Tauchmanová
Název: Význam somatických mutací u CLL. Katedra a fakulta: Buněčná biologie, PřF, UK, 2016. Vedoucí práce: Prof. Stopka
Diplomové práce (2)
Chia-Ling Chen
Název: Distribution of c-Kit Receptor on Hematopoietic Cells and its Downregulation by Stem Cell Factor. Katedra a fakulta: National Pingtung University of Science and Technology, Tchaj-wan, 2014. Vedoucí diplomové práce: Ko-Tung Chang, Ph.D. a prof. Nečas (1. LF UK)
Tereza Turková
Název: Vývoj myšího modelu pro studium chromatinu remodelačního genu Smarca5 (Snf2h). Katedra a fakulta: Biologie, Imunologie, PřF, UK, 2016. Vedoucí diplomové práce: Prof. Stopka
Disertační práce (2)
Petra Bašová
Název: Studium mechanismů agresivity akutní myeloidní leukemie v myším modelu nesoucím mutace genů Spi1 (PU.1) a Trp53. Katedra a fakulta: Biochemie, PřF, UK, 2014. Školitel: prof. Stopka
Anna Jonášová
Název: Patofyziologické aspekty myelodysplastického syndromu ve vztahu k efektu cílené imunomodulační a demetylační terapie. Fakulta: 1LF, UK, 2015. Školitel: prof. Stopka
Publikační výstupy a jiné dosažené výsledky hlavního řešitele a juniorských řešitelů (viz. příloha A3.Formulář – „Junior“).
A.Laslo P., Stopka T.: Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis. Book Chapter, 2014. “Epigenetics and Human Health” vydavatelství: Springer
Scientia foundantion award 2013/14
RNDr. Petra Bašová, Ph.D. ze skupiny doc. Stopky.
Za vynikající výsledky publikované v časopise Oncogene 2014 na téma Agresivní akutní myeloidní leukemie u myší s PU.1/p53 mutací.
Mgr. Karina Vargová, Ph.D. ze skupiny doc. Stopky.
Za vynikající výsledky publikované v disertační práci s názvem Role onkogenní mikroRNA-155 a proto-onkogenu MYB u chronické lymfatické leukémie.
Studentská vědecká konference 1. LFUK
Mgr. Kateřina Faltusová ze skupiny prof. Nečase, 1. cena v kategorii studentů Ph.D. – teoretické sekci 15. konference SVK, květen 2014 (rozšířený abstrakt, otištěný ve sborníku z SVK konference, ISBN 978-80-7492-150-6).
Cena České hematologické společnosti za nejlepší publikaci v oboru za rok 2015 obdržela MUDr. Magdalena Klánová za práci: Targeting of BCL2 family proteins with ABT-199 and homoharringtonine reveals BCL2- and MCL1-dependent subgroups of diffuse large B-cell lymphoma. Clin Cancer Res. Clin Cancer Res. 2016 Mar 1;22(5):1138-49. doi: 10.1158/1078-0432.CCR-15-1191.
Genes, Genetics & Genomics (G3) 2012. International Symposium on Gene Regulation in Normal and Pathologic States.
Genes, Genetics & Genomics (G3) 2013. International Symposium on Gene Regulation in Normal and Pathologic States.
Genes, Genetics & Genomics (G3) 2014. International Symposium on Gene Regulation in Normal and Pathologic States.
Genes, Genetics & Genomics (G3) 2014. John Strouboulis
Genes, Genetics & Genomics (G3) 2015: Frank Rosenbauer, Peter Valent, Josef T Prchal
Genes, Genetics & Genomics (G3) 2016: Michael Deininger and Eric Bouhassira
Genes, Genetics & Genomics (G3) 2017: Britta Will, Meritxell Alberich Jorda, Annalisa di Ruscio, Gerhard Behre, Sheela Abraham, Martin Kortüm, Jaroslav Doležel
Genes, Genetics & Genomics (G3) 2018: Satu Mustjoki, Andreas Burchert, Ingo Roeder, Leylah Drusbosky
Genes, Genetics & Genomics (G3) 2019: Torsten Haferlach, Tomasz Stoklosa,Tomáš Stopka, Jiří Zavadil, Michael Korenjak
Semináře UNCE (2x ročně)